Solving poor solubility [pharmaceutical technology]

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Solving poor solubility [pharmaceutical technology]
Engineering Village 2
2006 Elsevier Inc.
Accession number: 9038755

Title: Solving poor solubility [pharmaceutical technology]

Authors: Harris, R.1

Author affiliation: 1 Penn Pharm., Penn Pharm. Services Ltd., Tredegar, UK

Serial title: Manufacturing Chemist

Abbreviated serial title: Manuf. Chem. (UK)

Volume: 77

Issue: 3

Publication date: March 2006

Pages: 33-4

Language: English

ISSN: 0262-4230

CODEN: MACSAS

Document type: Journal article (JA)

Publisher: Polygon Media

Country of publication: UK

Material Identity Number: F619-2006-003

Abstract: Advances in combinatorial chemistry and high-throughput screening techniques are producing more drug candidates with greater specificity towards biological targets. However, a great many of the compounds coming through the development pipelines are Class II drugs (BCS classification), which means that they exhibit good permeability and, hence, poor water solubility. There are often problems associated with oral administration of this category of drug due to the limited solubility in the aqueous environment within the gastrointestinal tract. The prime objective for the pharmaceutical scientist is to improve the water solubility of drugs through chemical modification, physical modification, or formulation development. Developments in formulation science have included the use of mixtures of lipidic excipients and surfactants to produce self-emulsifying drug delivery systems and self-microemulsifying drug delivery systems for the oral administration of poorly water soluble drugs. New technologies for increased oral bioavailability and better encapsulation compatibility are also available

Number of references: 6

Inspec controlled terms: coatings - drugs - permeability - pharmaceutical industry - pharmaceutical technology - solubility

Uncontrolled terms: Class II drugs - permeability - water solubility - chemical modification - physical modification - formulation development - lipidic excipients - self-emulsifying drug delivery systems - self-microemulsifying drug delivery systems - oral bioavailability - encapsulation compatibility

Inspec classification codes: E3626A Pharmaceutical industry - E1780 Products and commodities - E1525 Industrial processes

Treatment: Practical (PRA)

Discipline: Manufacturing and production engineering (E)

Database: Inspec

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